Protein Details: Voltage-gated sodium channel subunit beta-3
Protein ID
ICDB_Pro_1215
Protein Name
Voltage-gated sodium channel subunit beta-3
Gene Name
Scn3b
Organism
Mus musculus (Mouse)
Length
215 amino acids
AlphaFoldDB
AF-Q8BHK2-F1-model_v4.pdb
Function
Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity).
Sequence
MPAFNRLLPLASLVLIYWVRVCFPVCVEVPSETEAVQGNSMKLRCISCMKREEVEATTVVEWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLFIEMIYCYRKVSKAEEAAQENASDYLAIPSENKENSVVPVEE
PDB Structures
Ligand Binding
Binding Site
Disease
Location
in mature myelinated axons
DOI ID
10.1126/science.1112014; 10.1016/j.cell.2010.12.001
RefSeq
NP_001077386.1; NP_001273543.1; NP_839941.1; XP_006510297.1